M6034
IgG2a, Lambda from murine myeloma
clone HOPC-1, purified immunoglobulin, buffered aqueous solution
Synonim(y):
Mouse IgG2a-λ
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About This Item
pochodzenie biologiczne
mouse
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
klon
HOPC-1, monoclonal
Postać
buffered aqueous solution
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
Opis ogólny
An immunoglobulin has two heavy chain and two light chain connected by disulfide bond. It is a glycoprotein. Rat has five immunoglobulin classes- IgM, IgG, IgA, IgD and IgGE. Immunoglobulin G (IgG) is a major class of immunoglobulin. IgG has four subclasses- IgG1, IgG2a, IgG2b and IgG2c.
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections
IgG2a, λ from murine myeloma specifically recognizes mouse IgG2a. Specificity of the mouse IgG2a, λ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgG1, IgG2a, IgG2b and IgG3.
IgG2a, λ from murine myeloma specifically recognizes mouse IgG2a. Specificity of the mouse IgG2a, λ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgG1, IgG2a, IgG2b and IgG3.
Zastosowanie
IgG2a, Lambda from murine myeloma has been used to standardize the enzyme-linked immunosorbent assay (ELISA) assay.
Działania biochem./fizjol.
Immunoglobulin G (IgG) mainly helps in immune defense. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.
Postać fizyczna
Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
The Laboratory Rat (1998)
The Immunoglobulins: Structure and Function (1998)
Molecular Genetics of Immunoglobulin, 17 (1987)
A human immunoglobulin lambda locus is similarly well expressed in mice and humans
Popov AV, et al.
The Journal of Experimental Medicine, 189(10), 1611-1620 (1999)
A V Popov et al.
The Journal of experimental medicine, 189(10), 1611-1620 (1999-05-20)
Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) lambda light (L) chain locus in germline configuration were created. The introduced translocus on a yeast artificial chromosome (YAC) accommodates the most proximal Iglambda variable region (V) gene cluster
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