Przejdź do zawartości
Merck
Wszystkie zdjęcia(1)

Dokumenty

G3295

Sigma-Aldrich

GW0742

≥98% (HPLC)

Synonim(y):

4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wszystkie zdjęcia(1)

About This Item

Wzór empiryczny (zapis Hilla):
C21H17F4NO3S2
Numer CAS:
317318-84-6
Masa cząsteczkowa:
471.49
Numer MDL:
MFCD07369423
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24895123
NACRES:
NA.77

Próba

≥98% (HPLC)

Postać

powder

kolor

white

mp

134.5-135.5 °C

rozpuszczalność

DMSO: >5 mg/mL
H2O: insoluble

inicjator

GlaxoSmithKline

temp. przechowywania

2-8°C

ciąg SMILES

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

Klucz InChI

HWVNEWGKWRGSRK-UHFFFAOYSA-N

informacje o genach

human ... PPARA(5465) , PPARD(5467) , PPARG(5468)

Działania biochem./fizjol.

GW0742 is a highly selective PPARδ agonist. EC50 = 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

Cechy i korzyści

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informacje prawne

Sold for research purposes under agreement from Glaxo­Smith­Kline
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Klienci oglądali również te produkty

Slide 1 of 8

1 of 8

Pioglitazone hydrochloride ≥98% (HPLC)

Sigma-Aldrich

E6910

Pioglitazone hydrochloride

GW1929 hydrate >98% (HPLC), solid

Sigma-Aldrich

G5668

GW1929 hydrate

Ciprofibrate

Sigma-Aldrich

C0330

Ciprofibrate

Ciglitizone ≥98% (HPLC)

Sigma-Aldrich

C3974

Ciglitizone

Bezafibrate ≥98%, solid

Sigma-Aldrich

B7273

Bezafibrate

Ospemifene ≥98% (HPLC)

Sigma-Aldrich

SML0996

Ospemifene

Fenofibrate ≥99%, powder

Sigma-Aldrich

F6020

Fenofibrate

Troglitazone ≥98% (HPLC)

Sigma-Aldrich

T2573

Troglitazone

Bruce E Heck et al.
Cell transplantation, 26(8), 1405-1417 (2017-09-14)
Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA, and the population is expected to reach 67 million in the United States by 2030. Thus
Koichiro Kawaguchi et al.
FEBS open bio, 6(3), 190-199 (2016-04-06)
Fatty acid-binding proteins (FABPs) are responsible for binding and storing hydrophobic ligands such as long-chain fatty acids, and for transporting these ligands to the appropriate compartments within the cell. The present study demonstrates that the FABP5 gene is upregulated in
Daniel Morales-Cano et al.
Clinical science (London, England : 1979), 130(20), 1823-1836 (2016-07-15)
PPARβ/δ activation protects against endothelial dysfunction in diabetic models. Elevated glucose is known to impair cAMP-induced relaxation and Kv channel function in coronary arteries (CA). Herein, we aimed to analyse the possible protective effects of the PPARβ/δ agonist GW0742 on
Luka Opitz et al.
Journal of anatomy, 231(6), 970-977 (2017-08-09)
Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions
Amar Bahadur Singh et al.
The Journal of biological chemistry, 292(3), 884-897 (2016-12-04)
Peroxisome proliferator-activated receptor δ (PPARδ) regulates many genes involved in lipid metabolism. Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty
Wyświetl wszystkie powiązane dokumenty

Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.

Skontaktuj się z zespołem ds. pomocy technicznej