E3763

Resorufin ethyl ether

≥98% (TLC), powder

• Synonim(y): 7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O⁷-Ethylresorufin
• Wzór empiryczny (zapis Hilla): C₁₄H₁₁NO₃
• Numer CAS: 5725-91-7
• Masa cząsteczkowa: 241.24
• Beilstein: 225973
• Numer MDL: MFCD00037661
• Kod UNSPSC: 12161501
• Identyfikator substancji w PubChem: 24894527
• NACRES: NA.47

Właściwości

• Poziom jakości: 200
• Próba: ≥98% (TLC)
• Postać: powder
• warunki przechowywania: (Tightly closed. Dry)
• metody: activity assay: suitable
• kolor: orange to red
• mp: 223-225 °C (lit.)
• rozpuszczalność: chloroform: 9.80-10.20 mg/mL, clear, orange
• przydatność: suitable for fluorescence
• temp. przechowywania: −20°C
• ciąg SMILES: CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
• InChI: 1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
• Klucz InChI: ZOSYTBPPLWBBKM-UHFFFAOYSA-N

Opis

Opis ogólny

Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.

Resorufin is the reduced product of resazurin, also termed as Alamar Blu. It exhibits fluorescence at longer wavelengths and is flexible for modification in its hydroxyl group.

Research area: Cell Signaling

Zastosowanie

Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).

Substraty

Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)