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Dokumenty

A6987

Sigma-Aldrich

Ceftazidime hydrate

Synonim(y):

1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum

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About This Item

Wzór empiryczny (zapis Hilla):
C22H22N6O7S2 · xH2O
Numer CAS:
120618-65-7
Masa cząsteczkowa:
546.58 (anhydrous basis)
Numer MDL:
MFCD00153936
Kod UNSPSC:
51284108
Identyfikator substancji w PubChem:
329770910
NACRES:
NA.85

opis

does not contain sodium carbonate

Próba

95.0-102.0% anhydrous basis

Postać

powder or crystals

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria

Tryb działania

cell wall synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C([O-])=O)c4csc(N)n4)C(O)=O

InChI

1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1

Klucz InChI

NMVPEQXCMGEDNH-TZVUEUGBSA-N

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Opis ogólny

Broad spectrum antibiotic; third generation cephalosporin

Zastosowanie

Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.

Działania biochem./fizjol.

Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.
This page may contain text that has been machine translated.

Piktogramy

Health hazard
GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H317,H334

Zwroty wskazujące środki ostrożności

P261 - P280 - P342 + P311

Klasyfikacja zagrożeń

Resp. Sens. 1 - Skin Sens. 1

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Supelco

PHR1885

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USP

1392454

Meropenem

Imipenem Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1796

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Meropenem trihydrate European Pharmacopoeia (EP) Reference Standard

Y0001252

Meropenem trihydrate

Cefotaxime sodium salt potency: 916-964 μg per mg

Sigma-Aldrich

C7912

Cefotaxime sodium salt

Amikacin disulfate salt potency: 674-786 μg per mg (as amikacin base)

Sigma-Aldrich

A1774

Amikacin disulfate salt

Supelco

Supelco

PHR1763

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Meropenem trihydrate ≥98% (HPLC)

Sigma-Aldrich

M2574

Meropenem trihydrate

Bacitracin from Bacillus licheniformis, ≥65 IU/mg

Sigma-Aldrich

11702

Bacitracin

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The Journal of antimicrobial chemotherapy, 70(5), 1434-1442 (2015-02-26)
Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is concerning. Here, our objective was to optimize colistin combinations against Pseudomonas aeruginosa by profiling the time course of synergistic
David M P De Oliveira et al.
Science translational medicine, 12(570) (2020-11-20)
The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a critical threat to human health, and alternative treatment strategies are urgently required. We investigated the ability of the hydroxyquinoline analog ionophore PBT2 to restore antibiotic sensitivity
Borys Snopok et al.
The Analyst, 140(9), 3225-3232 (2015-03-13)
An ultra-sensitive gas phase biosensor/tracer/bio-sniffer is an emerging technology platform designed to provide real-time information on air-borne analytes, or those in liquids, through classical headspace analysis. The desired bio-sniffer measures gaseous 17α- ethinylestradiol (ETED) as frequency changes on a quartz
Ruud R G Bueters et al.
Pediatric research, 76(6), 508-514 (2014-08-29)
Many premature born neonates receive antibiotic drugs to treat infections, which are applied during active nephrogenesis. We studied the impact of clinical concentrations of gentamicin and alternatives, ceftazidime and meropenem, on ureteric branching. Mice metanephroi were dissected at embryonic day
Yung-Heng Hsu et al.
International journal of nanomedicine, 9, 4347-4355 (2014-09-24)
We developed biodegradable drug-eluting nanofiber-enveloped implants that provided sustained release of vancomycin and ceftazidime. To prepare the biodegradable nanofibrous membranes, poly(D,L)-lactide-co-glycolide and the antibiotics were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into biodegradable drug-eluting membranes, which were then enveloped

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