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Inne dokumenty

71230

Sigma-Aldrich

Thimerosal

97.0-101.0% (on dried substance, T)

Synonim(y):

2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate

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About This Item

Wzór liniowy:
2-(C2H5HgS)C6H4CO2Na
Numer CAS:
54-64-8
Masa cząsteczkowa:
404.81
Beilstein:
8169555
Numer WE:
200-210-4
Numer MDL:
MFCD00013062
Kod UNSPSC:
51101500
Identyfikator substancji w PubChem:
329763125
NACRES:
NA.21

Poziom jakości

200

Próba

97.0-101.0% (on dried substance, T)

Postać

powder

mp

234-237 °C (dec.) (lit.)

Tryb działania

enzyme | inhibits

ciąg SMILES

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

Klucz InChI

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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Działania biochem./fizjol.

Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.

Komentarz do analizy

Solubility (EP/BP) Freely soluble in water, sparingly soluble or soluble in ethanol (96%), practically insoluble in ether and methylene cholride.

Inne uwagi

As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. Sales of thimerosal will be restricted for approved applications only.
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Certyfikaty analizy (CoA)

Lot/Batch Number
089M4021V
029M4106V
029M4106V
048M4034V
127M4144V

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Antimicrobial agents and chemotherapy, 48(12), 4848-4854 (2004-11-25)
Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is
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Hyperinsulinism with islet cell hyperplasia is a frequent complication, of unknown cause, in hemolytic disease of the newborn, occurring in Rh(D)-positive infants of Rh-isoimmunized Rh(D)-negative mothers, but not in infants with other hemolytic disorders. We investigated the possibility that trans-placentally
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Despite the common use of Thimerosal as a preservative in childhood vaccines since the 1930s, there are not many studies on ethylmercury toxicokinetics and toxicodynamics in infants. The knowledge of ethylmercury's potential adverse effects is derived mostly from parallel methylmercury
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Although the assertion of a link between vaccines and autism has been scientifically rejected, the theory continues to be popular and may influence the attitudes of parents of children with autism spectrum disorders. The authors sought to assess how often
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