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Supelco

Diosmin

analytical standard

Synonim(y):

3′,5,7-Trihydroxy-4′-methoxyflavone 7-rutinoside, Barosmin, Buchu resin, Diosmetin 7-O-rhamnosylglucoside, Diosmetin 7-rutinoside

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About This Item

Wzór empiryczny (zapis Hilla):
C28H32O15
Numer CAS:
520-27-4
Masa cząsteczkowa:
608.54
Numer WE:
208-289-7
Numer MDL:
MFCD00009772
Kod UNSPSC:
85151701
Identyfikator substancji w PubChem:
329759466
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

100

Próba

≥90% (HPLC)

okres trwałości

limited shelf life, expiry date on the label

metody

HPLC: suitable
gas chromatography (GC): suitable

zanieczyszczenia

≤10% water

Zastosowanie

food and beverages

format

neat

temp. przechowywania

2-8°C

ciąg SMILES

COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2

InChI

1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

Klucz InChI

GZSOSUNBTXMUFQ-YFAPSIMESA-N

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Opis ogólny

Diosmin is a flavonoid glycoside that occurs naturally as an active constituent of citrus fruits.(1) It possess a wide range of pharmacological properties like antioxidant, anticarcinogenic, blood-lipid lowering and also anti-inflammatory activities. Diosmin can also find applications in the healing of venous ulcers, enhancement of microcirculation and improvement of venous tone.

Zastosowanie

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Działania biochem./fizjol.

Citrus flavonoid. Modification of hesperidin. Studied for its chemopreventive properties, including anti-proliferative and anti-inflammatory.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

Inne uwagi

This compound is commonly found in plants of the genus: mentha
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Choose from one of the most recent versions:

Certyfikaty analizy (CoA)

Lot/Batch Number
BCCC6711
BCBW2895
BCBR2970V
BCBM1831V
BCBF4595V

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Eriocitrin ≥98.0% (HPLC)

Sigma-Aldrich

45714

Eriocitrin

Hesperidin ≥80% (HPLC)

Sigma-Aldrich

H5254

Hesperidin

Kaempferol 3-glucoside primary reference standard

04500585

Kaempferol 3-glucoside

Hesperidin European Pharmacopoeia (EP) Reference Standard

Y0001203

Hesperidin

Orientin ≥97% (HPLC)

Sigma-Aldrich

O9765

Orientin

Chlorogenic acid European Pharmacopoeia (EP) Reference Standard

Y0000569

Chlorogenic acid

Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations
Kanaze IF, et al.
Journal of Pharmaceutical and Biomedical Analysis, 33, 243-249 (2003)
Chung Sim Lim et al.
Journal of vascular surgery, 56(4), 1069-1077 (2012-06-09)
Doxycycline and micronized purified flavonoid fraction (MPFF) modulate vein wall remodeling that may be associated with hypoxia in varicose veins (VVs), vein graft stenosis, and deep venous thrombosis. We recently reported that in vitro exposure of non-VV (NVVs) and VVs
Subramani Srinivasan et al.
Chemico-biological interactions, 195(1), 43-51 (2011-11-08)
Oxidative stress has been suggested as a contributory factor in development and complication of diabetes. The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid
Joseph D Raffetto et al.
Journal of vascular surgery, 54(2), 489-496 (2011-04-19)
Saponosides (horse chestnut seed extract, escin) and flavonoids (diosmin, Daflon 500, Servier, France) exhibit venotonic properties that have been utilized in treatment of varicose veins. However, the cellular mechanisms underlying the venotonic properties of escin and diosmin are unclear. Because
Mir Tahir et al.
Alcohol (Fayetteville, N.Y.), 47(2), 131-139 (2013-02-20)
The present investigation was designed to evaluate the efficacy of diosmin against ethanol-induced hepatotoxicity in rats by modulating various mechanisms including ethanol metabolizing enzymes, generation of free radicals, imbalance in oxidant-antioxidant status, oxidative damage to membrane lipids, activation of transcription
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