MABN45
Anti-Tdp43 Antibody, clone 3H8
clone 3H8, from mouse
Synonim(y):
TAR DNA-binding protein 43, TDP-43, TDP43, TAR DNA binding protein-43
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
3H8, monoclonal
reaktywność gatunkowa
human, mouse, rat
metody
immunohistochemistry: suitable
western blot: suitable
izotyp
IgG1
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... TARDBP(23435)
Opis ogólny
TAR DNA-binding protein 43 (Tdp43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in Tdp43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson′s disease and Alzheimer′s disease.
Immunogen
His-tagged recombinant protein corresponding to the N-terminus of human Tdp43.
Zastosowanie
Detect TDP using this mouse monoclonal antibody, Anti-Tdp43 Antibody, clone 3H8 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Tdp43 in human frontal lobe, human cerebellum, and rat cerebellum tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
Jakość
Evaluated by Western Blotting in mouse brain nuclear extract tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Tdp43 in 10 µg of mouse brain nuclear extract tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Tdp43 in 10 µg of mouse brain nuclear extract tissue lysate.
Opis wartości docelowych
~43 kDa observed
Postać fizyczna
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide with 10% glycerol.
Przechowywanie i stabilność
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients.
Lee, S; Levin, M
F1000Research null
Kohei Nishino et al.
Acta neuropathologica communications, 7(1), 118-118 (2019-07-28)
Intracellular mislocalization of TAR DNA-binding protein 43 (TDP-43), a nuclear DNA/RNA-binding protein involved in RNA metabolism, is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Although the aggregation-prone, TDP-43 C-terminal domain is widely considered as a key component of TDP-43
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