14-628-M
TBK1 Protein, active, 10 µg
Active, N-terminal His6-tagged, recombinant, full length, human TBK1, for use in Kinase Assays.
Synonim(y):
NAK, NF-kappa-B-activating kinase, T2K, TANK-binding kinase-1
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About This Item
Kod UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in baculovirus infected Sf21 cells
okres trwałości
6 mo.
masa cząsteczkowa
Mw 85.7 kDa
producent / nazwa handlowa
Upstate®
metody
activity assay: suitable (kinase)
numer dostępu NCBI
numer dostępu UniProt
temp. przechowywania
−70°C
informacje o genach
human ... TBK1(29110)
Opis ogólny
Research area: Cancer
Protein Target: TBK1, Target Sub-Family: Misc
TANK-binding kinase-1 (TBK1), also known as NF-κB activating kinase (NAK), is a serine-threonine kinase from the IκB kinase (IKK) family. It is encoded by tbk1 gene and is ubiquitously expressed in various tissues.
Protein Target: TBK1, Target Sub-Family: Misc
TANK-binding kinase-1 (TBK1), also known as NF-κB activating kinase (NAK), is a serine-threonine kinase from the IκB kinase (IKK) family. It is encoded by tbk1 gene and is ubiquitously expressed in various tissues.
Zastosowanie
Research Category
Inflammation & Immunology
Inflammation & Immunology
Działania biochem./fizjol.
TANK-binding kinase-1 (TBK1) is mainly involved in activating interferon regulatory transcription factor 3/7 (IRF 3/7) and nuclear factor (NF-κB) signaling pathways, which are essential for regulating the production of type I interferons (IFN), including IFN-α and IFN-β and the activation of innate immunity. In addition, TBK1 also mediates various other cellular processes including autophagy, proliferation, immune response/inflammation survival, insulin signaling, and metabolism. TBK1 plays a significant role in cancer pathogenesis. In cancer cells, it enhances tumor growth by activating proliferation and survival signaling, promoting tumor-promoting cytokine production, and facilitating the secretion of immunosuppressive inflammatory cytokines. Overexpression of tbk1 gene is observed in various cancers including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDA), cholangiocarcinoma, clear cell renal cell carcinoma (ccRCC), adult T-cell leukemia, melanoma, esophageal cancer, and breast cancer.
Jakość
routinely evaluated by phosphorylation of CK1tide (12-529)
Postać fizyczna
Ni2+/NTA-agarose
Przechowywanie i stabilność
6 months at -70°C
Inne uwagi
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
André Richters et al.
ACS chemical biology, 10(1), 289-298 (2014-12-30)
The cytosolic Ser/Thr kinase TBK1 was discovered to be an essential element in the mediation of signals that lead to tumor migration and progression. These findings meet the need for the identification of novel tool compounds and potential therapeutics to
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