VHL
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Synonimy:
HRCA1, RCA1, VHL1, pVHL
Gatunek:
Human VHL (7428), Mouse Vhl (22346), Rat Vhl (24874), fruit fly Vhl (53433), domestic cat VHL (101092590), dog VHL (494000), chicken VHL (416117), Zebrafish vhl (791202), cow VHL (540957), sheep VHL (101122897)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(7428) Summary: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(22346) von Hippel-Lindau tumor suppressor
- Rat(24874) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- fruit fly(53433) von Hippel-Lindau
- domestic cat(101092590) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- dog(494000) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- chicken(416117) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- Zebrafish(791202) von Hippel-Lindau tumor suppressor
- cow(540957) von Hippel-Lindau tumor suppressor
- sheep(101122897) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- domestic guinea pig(100729230) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-VHL antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
immunohistochemistry
Monoclonal Anti-VHL antibody produced in mouse, clone 1G12, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-VHL antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
canine, human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Przeciwciało anty-VHL, klon 11E12, clone 11E12, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunoprecipitation (IP)
western blot
western blot
Przeciwciało anty-Vhl wytwarzane u królików, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Proteins
Numer produktu
Opis
Gatunek
Kompleks białkowy VHL, aktywny, 10 µg, Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
Gatunek
human