TERT
telomerase reverse transcriptase
Synonimy:
CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
Gatunek:
Human TERT (7015), Mouse Tert (21752), Rat Tert (301965), Thale Cress TERT (831548), domestic cat TERT (100144612), dog TERT (403412), chicken TERT (420972), Zebrafish tert (796551), naked mole-rat Tert (101706965), domestic guinea pig Tert (100732437) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(7015) Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
- Mouse(21752) telomerase reverse transcriptase
- Rat(301965) telomerase reverse transcriptase
- Thale Cress(831548) telomerase reverse transcriptase
- domestic cat(100144612) telomerase reverse transcriptase
- dog(403412) telomerase reverse transcriptase
- chicken(420972) telomerase reverse transcriptase
- Zebrafish(796551) telomerase reverse transcriptase
- naked mole-rat(101706965) telomerase reverse transcriptase
- domestic guinea pig(100732437) telomerase reverse transcriptase
- cow(518884) telomerase reverse transcriptase
- sheep(100126866) telomerase reverse transcriptase
- sheep(101112422) telomerase reverse transcriptase
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-phospho-Telomerase (pSer824) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot
western blot
Anti-TERT (human) Antibody, clone 2C4, clone 2C4, from mouse,
Reaktywność gatunkowa
human
Zastosowanie
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-TERT antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
western blot
Anty-TERT, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-TERT Antibody, from rabbit, purified by affinity chromatography,
Reaktywność gatunkowa
human, mouse, rat, rhesus macaque
Zastosowanie
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Numer produktu
Opis
Gatunek
esiRNA
Numer produktu
Opis
Gatunek