RB1
retinoblastoma 1
Synonimy:
OSRC, RB, p105-Rb, pRb, pp110
Gatunek:
Human RB1 (5925), Mouse Rb1 (19645), Rat Rb1 (24708), cow RB1 (534712), sheep RB1 (100144755), Domestic Rabbit RB1 (100357431), naked mole-rat Rb1 (101703701), domestic guinea pig Rb1 (100716297), Zebrafish rb1 (777733), chicken RB1 (386582) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(5925) Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Mouse(19645) retinoblastoma 1
- Rat(24708) retinoblastoma 1
- cow(534712) retinoblastoma 1
- sheep(100144755) retinoblastoma 1
- Domestic Rabbit(100357431) retinoblastoma 1
- naked mole-rat(101703701) retinoblastoma 1
- domestic guinea pig(100716297) retinoblastoma 1
- Zebrafish(777733) retinoblastoma 1
- chicken(386582) retinoblastoma 1
- dog(476915) retinoblastoma 1
- domestic cat(101101356) retinoblastoma 1
- Horse(100057080) retinoblastoma 1
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anty RB, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-Rb Antibody, clone 2M15 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
ANTI-PHOSPHO-RB(S612) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Anty-Fosfo-RB-S780, ,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot
western blot
Kits
Numer produktu
Opis
Gatunek
CpG WIZ™ RB1 - Test PCR specyficzny dla metylacji, MSP, performed using the CpGenome DNA Modification Kit & the CpG WIZ RB1 Amplification Kit, permits sensitive detection of altered DNA.,
Gatunek
human
Proteins
Numer produktu
Opis
Gatunek
Retinoblastoma protein human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Gatunek
human
Białko retinoblastoma (aa 773-928), Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.,
Gatunek
human