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Merck

MYLK

myosin light chain kinase

Synonimy:
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(4638) Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
  • Mouse(107589) myosin, light polypeptide kinase
  • Rat(288057) myosin light chain kinase
  • chicken(396445) myosin light chain kinase
  • dog(488012) myosin light chain kinase
  • Horse(100070482) myosin light chain kinase
  • cow(338037) myosin light chain kinase
  • naked mole-rat(101704236) myosin light chain kinase
  • Domestic Rabbit(100009143) myosin light chain kinase
  • domestic guinea pig(100714177) myosin light chain kinase
  • sheep(443334) myosin light chain kinase

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Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse, clone K36, ascites fluid,
Reaktywność gatunkowa
avian, mammals
Zastosowanie
immunoprecipitation (IP)
microarray

western blot
Monoclonal Anti-MYLK antibody produced in mouse, clone 1D1, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
Anti-MYLK antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
proximity ligation assay
western blot
Anti-MYLK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-MYLK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
ML-7, powder,
Gatunek
human

Proteins

Numer produktu
Opis
Gatunek
Białko MLCK, aktywne, 10 µg, Active, N-terminal 6His-tagged, recombinant, human MLCK, amino acids 1425-1771, for use in Kinase Assays.,
Gatunek
human
MLCK (1425-1776), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human MYLK (2),
Gatunek
human
MISSION® esiRNA, targeting human MYLK (1),
Gatunek
human
MISSION® esiRNA, targeting mouse Mylk,
Gatunek
mouse