JAK1
Janus kinase 1
Synonimy:
JAK1A, JAK1B, JTK3
Gatunek:
Human JAK1 (3716), Mouse Jak1 (16451), Rat Jak1 (84598), Zebrafish jak1 (30280), domestic cat JAK1 (101084377), Horse JAK1 (100054008), cow JAK1 (537201), dog JAK1 (442952), chicken JAK1 (395681), domestic guinea pig Jak1 (100726895) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(3716) Summary: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
- Mouse(16451) Janus kinase 1
- Rat(84598) Janus kinase 1
- Zebrafish(30280) Janus kinase 1
- domestic cat(101084377) Janus kinase 1
- Horse(100054008) Janus kinase 1
- cow(537201) Janus kinase 1
- dog(442952) Janus kinase 1
- chicken(395681) Janus kinase 1
- domestic guinea pig(100726895) Janus kinase 1
- naked mole-rat(101710283) Janus kinase 1
- sheep(101110716) Janus kinase 1
- Domestic Rabbit(100352594) Janus kinase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Numer produktu
Opis
Gatunek
Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-JAK1 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Przeciwciało anty-fosfo-Jak1-Y1022/1023produkowane u królików, ,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunofluorescence
western blot
western blot
Przeciwciało anty-JAK1, klon 73, clone 73, from mouse,
Reaktywność gatunkowa
xenopus, canine, chicken, human, mouse, rat
Zastosowanie
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Numer produktu
Opis
Gatunek
Jak1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Gatunek
human
Białko JAK1, aktywne, 10 µg, Active, N-terminal GST-tagged, recombinant, human JAK1, amino acids 866-end, expressed by baculovirus in Sf21 insect cells. Activated in vitro by auto-phosphorylation. For use in Kinase Assays.,
Gatunek
human