CBL
Cbl proto-oncogene, E3 ubiquitin protein ligase
Synonimy:
C-CBL, CBL2, FRA11B, NSLL, RNF55
Gatunek:
Human CBL (867), Mouse Cbl (12402), Rat Cbl (500985), naked mole-rat Cbl (101710004), domestic guinea pig Cbl (100725041), sheep CBL (101115401), Domestic Rabbit CBL (100342595), Zebrafish cbl (492364), Thale Cress CBL (824872), cow CBL (527418) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(867) Summary: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
- Mouse(12402) Casitas B-lineage lymphoma
- Rat(500985) Cbl proto-oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101710004) Cbl proto-oncogene, E3 ubiquitin protein ligase
- domestic guinea pig(100725041) Cbl proto-oncogene, E3 ubiquitin protein ligase
- sheep(101115401) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Domestic Rabbit(100342595) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Zebrafish(492364) Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Thale Cress(824872) cystathionine beta-lyase
- cow(527418) Cbl proto-oncogene, E3 ubiquitin protein ligase
- Horse(100071403) Cbl proto-oncogene, E3 ubiquitin protein ligase
- domestic cat(101096508) Cbl proto-oncogene, E3 ubiquitin protein ligase
- dog(489369) Cbl proto-oncogene, E3 ubiquitin protein ligase
- chicken(374038) Cbl proto-oncogene, E3 ubiquitin protein ligase
- fruit fly(38961) CG7037 gene product from transcript CG7037-RB
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-phospho-CBL (pTyr674) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CBL antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot
western blot
Anti-phospho-CBL (pTyr700) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Przeciwciało anty-fosfo-CBL-Y731wytwarzane u królika, ,
Reaktywność gatunkowa
human
Zastosowanie
western blot
Przeciwciało anty-fosfo-CBL-Y700produkowane u królików, ,
Reaktywność gatunkowa
human
Zastosowanie
western blot