Przejdź do zawartości
Merck

EGFR

epidermal growth factor receptor

Synonimy:
ERBB, ERBB1, HER1, PIG61, mENA
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Numer produktu
Opis
Gatunek
Phospho-EGFR (pTyr1045) ELISA Kit, for detection of human phospho-egfr (pTyr1045) in cell and tissue lysates,
Gatunek
human
Phospho-EGFR (pTyr1068) ELISA Kit, for detection of human phospho-egfr (pTyr1068) in cell and tissue lysates,
Gatunek
human
Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates,
Gatunek
human
Cell-Based ELISA for detecting phospho-EGFR (pTyr1068) in cultured cell lines, 96 assays,
Gatunek
human
Cell-Based ELISA for detecting phospho-EGFR (pTyr992) in cultured cell lines, 96 assays,
Gatunek
human

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
Tyrphostin AG 1478, ≥98%,
Gatunek
human, mouse
SU 5416, ≥98% (HPLC),
Gatunek
human, mouse
Genistein, synthetic, ≥98% (HPLC), powder,
Gatunek
mouse, human, rat
Genistein, from Glycine max (soybean), ~98% (HPLC),
Gatunek
mouse, human, rat

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoklonalny anty-EGFR PE wytwarzany u myszy, ,
Reaktywność gatunkowa
horse
Zastosowanie
flow cytometry
Anti-phospho-EGFR (pThr693) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-EGFR (pTyr1069) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
western blot
Anti-phospho-EGFR (pTyr1016) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Rabbit anti-EGFR Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunohistochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
DAPH, ≥98% (HPLC), solid,
Gatunek
human
Erlotinib hydrochloride, ,
Gatunek
human
Gefitinib for system suitability, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
PKI-166, ≥98% (HPLC),
Gatunek
human
Gefitinib, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human

Proteins

Numer produktu
Opis
Gatunek
EGF-receptor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Gatunek
human
EGFR Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Gatunek
human
Epidermal Growth Factor Receptor human, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Gatunek
human
Epidermal Growth Factor Receptor human, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Gatunek
human
EGFR (D746-750 T790M C797S), aktywny, PRECISIO® Kinase, recombinant,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting mouse Egfr,
Gatunek
mouse
MISSION® esiRNA, targeting human EGFR,
Gatunek
human