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  • Microfluidic-assisted fabrication of carriers for controlled drug delivery.

Microfluidic-assisted fabrication of carriers for controlled drug delivery.

Lab on a chip (2017-05-10)
Dongfei Liu, Hongbo Zhang, Flavia Fontana, Jouni T Hirvonen, Hélder A Santos
ABSTRACT

The microfluidic technique has brought unique opportunities toward the full control over the production processes for drug delivery carriers, owing to the miniaturisation of the fluidic environment. In comparison to the conventional batch methods, the microfluidic setup provides a range of advantages, including the improved controllability of material characteristics, as well as the precisely controlled release profiles of payloads. This review gives an overview of different fluidic principles used in the literature to produce either polymeric microparticles or nanoparticles, focusing on the materials that could have an impact on drug delivery. We also discuss the relations between the particle size and size distribution of the obtained carriers, and the design and configuration of the microfluidic setups. Overall, the use of microfluidic technologies brings exciting opportunities to expand the body of knowledge in the field of controlled drug delivery and great potential to clinical translation of drug delivery systems.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Various Height Reaction Chamber Chip, Fluidic 1100 PS
Sigma-Aldrich
Pearl-chain mixer, Fluidic 658, PC
Sigma-Aldrich
Snowman Mixer Chip, Fluidic 1108, COC
Sigma-Aldrich
3D-Serpentine Mixer, Fluidic 1079, PC
Sigma-Aldrich
Spiral sorter, Fluidic 382, COP
Sigma-Aldrich
Male mini luer plug, single, Fluidic 334, PP
Sigma-Aldrich
Diffusion mixer chip, Fluidic 186, COP
Sigma-Aldrich
200 μl tank with Mini Luer interface, Fluidic 926, PP
Sigma-Aldrich
Phase Guide Mixer Chip, Fluidic 533, COC
Sigma-Aldrich
Various Height Reaction Chamber Chip, Fluidic 1099 PS
Sigma-Aldrich
Diffusion mixer chip, Fluidic 186, PC
Sigma-Aldrich
Spiral sorter, Fluidic 382, PMMA
Sigma-Aldrich
Various Height Reaction Chamber Chip, Fluidic 1100 COC
Sigma-Aldrich
Pearl-chain mixer, Fluidic 658, COC
Sigma-Aldrich
Reaction chamber chip - 20 μl, Fluidic 556, COP
Sigma-Aldrich
Cross-shaped channel chip - 200 μm channel, Fluidic 394, PMMA with Luer Interface
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Cross-shaped channel chip - 75 μm channel, Fluidic 106, Cyclic Olefin Polymer (COP) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 200 μm channel, Fluidic 394, Cyclic Olefin Copolymer (COC) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 75 μm channel, Fluidic 106, Cyclic Olefin Copolymer (COP) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 200 μm channel, Fluidic 394, Cyclic Olefin Polymer (COP) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 50 μm channel, Fluidic 82, PMMA with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 75 μm channel (double T-junction), Fluidic 202, Cyclic Olefin Copolymer (COC) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 50 μm channel, Fluidic 82, Cyclic Olefin Copolymer (COC) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 75 μm channel (double T-junction), Fluidic 202, Cyclic Olefin Polymer (COP) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 50 μm channel (extended size platform ΙΙ), Fluidic 189, PMMA with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 50 μm channel (extended size platform ΙΙ), Fluidic 189, Cyclic Olefin Copolymer (COC) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 50 μm channel, Fluidic 82, Cyclic Olefin Polymer (COP) with Luer Interface
Sigma-Aldrich
Cross-shaped channel chip - 75 μm channel, Fluidic 106, PMMA with Luer Interface
Sigma-Aldrich
Male mini luer plug, single, Fluidic 334, TPE
Sigma-Aldrich
Reaction chamber chip - various volume chambers, Fluidic 620, COC