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Halogenation Reagents

AlkylFluor structure – a halogenation reagent

Halogenation is fundamental tool in the organic chemist toolbox for replacing a hydrogen atom with a halogen atom (fluorine, chlorine, bromide, or iodine). The use of halogenation reagents in various coupling protocols (i.e., Suzuki, Stille, Sonogashira) and nucleophilic substitution is prevalent and has been reported about in the scientific community.

While several synthetic methods for the introduction of a halogen exist, there is still a need for efficient and practical methods for introducing other halogen-containing structural elements, in particular at a late-stage in synthesis (esp. with high yields and under mild conditions). Our readily available halogenation reagents may be used in many stages of your synthesis and many are practical for use in late-stage development.

Our portfolio includes halogenation reagents for brominations, chlorinations, fluorinations, haloborations, and iodinations. With products such as AlkylFluor, XtalFluor®, PhenoFluor™, and PyFluor there are bench-stable reagent options for deoxyfluorination. We are dedicated to supporting all your explorations with these and more halogenated substrates.

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C–H functionalization is the reliable and predictable conversion of a C–H into a C–C, C–N, C–O, or C–X bond in a selective and controlled fashion.
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Cross-coupling is a common reaction in organic chemistry for the creation of C-C, C-N, and C-O bonds with the aid of a metal catalyst.
Fluorination
Fluorination is the introduction of fluorine to a compound via electrophilic fluorination, nucleophilic fluorination, difluoromethylation, trifluoromethylation, or perfluoroalkylation.
Metathesis
Olefin metathesis involves an organic reaction that redistributes fragments of alkenes (olefins) by cleavage and transformation of carbon-carbon double bonds.
Photocatalysis
Photoredox catalysis utilizes photocatalysts in the presence of visible light to form an array of synthetic transformations including, but not limited to, cross-coupling, C-H functionalization, alkene and arene functionalization, and trifluoromethylation.
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An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.
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