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A7785

Sigma-Aldrich

Apolipoprotein C-I from human plasma

≥95% (SDS-PAGE), lyophilized powder

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About This Item

CAS Number:
2235444-72-9
MDL number:
MFCD00162928
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

average mol wt 6.6 kDa

technique(s)

inhibition assay: suitable

UniProt accession no.

P02654

storage temp.

−20°C

Gene Information

human ... APOC1(341)

General description

Very low density lipoprotein.

Application

Apolipoprotein C-1 directly interferes with fatty acid uptake and is a major plasma inhibitor of cholesterol ester transfer protein. Apolipoprotein C-I has been used to develop a quantitative strategy, named secretome-derived isotopic tag (SDIT), to concurrently identify and quantify the adipocyte-secreted plasma proteins from normal and high-fat-diet (HFD) induced obese mice.

Biochem/physiol Actions

Interferes directly with fatty acid uptake and is the major plasma inhibitor of cholesterol ester transfer protein.

Physical form

Lyophilized from 10 mM NH4HCO3, pH 7.5

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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B S Suri et al.
The Biochemical journal, 178(2), 455-466 (1979-02-15)
1. The work reported was designed to provide quantitative information about the capacity of the extrahepatic tissues of the rat to degrade injected VLD lipoproteins (very-low-density lipoproteins, d less than 1.006) to LD lipoproteins (low-density lipoproteins, d 1.006--1.063) and to
Rong-Xia Li et al.
Journal of proteome research, 11(5), 2851-2862 (2012-03-13)
We developed a quantitative strategy, named secretome-derived isotopic tag (SDIT), to concurrently identify and quantify the adipocyte-secreted plasma proteins from normal and high-fat-diet (HFD) induced obese mice, based on the application of isotope-labeled secreted proteins from cultured mouse adipocytes as
Nathan L Meyers et al.
Biochemistry, 51(6), 1238-1248 (2012-01-24)
Apolipoprotein C-I (apoC-I) is an important constituent of high-density lipoprotein (HDL) and is involved in the accumulation of cholesterol ester in nascent HDL via inhibition of cholesterol ester transfer protein and potential activation of lecithin:cholesterol acyltransferase (LCAT). As the smallest

Articles

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

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