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Merck

HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

Synonyms:
CD, CELIAC1, DQ-A1, GSE, HLA-DQA
Species:
Human HLA-DQA1 (3117)
UniProtKB ID:
P01909, O19630, O19706, P01907, P01908, P04225, P04226, P05536
Gene ID:
  • Human(3117) Summary: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4700650
Monoclonal Anti-HLA-DQ1-DQ3 antibody produced in mouse, clone HL-37, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
HPA012315
Anti-HLA-DQA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
SAB5700946
Anti-HLA-DQA1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
SAB1402223
Monoclonal Anti-HLA-DQA1 antibody produced in mouse, clone 1A3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
MABF3078
Anti-HLA‑DQA1 Antibody, clone SPV-L3, ,
Species Reactivity
human
Application
blocking
flow cytometry
immunoprecipitation (IP)

esiRNA

Product Number
Description
Species
EHU111801
MISSION® esiRNA, targeting human HLA-DQA1,
Species
human