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  • Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs.

Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs.

Scientific reports (2017-07-08)
Konstantinos E Papathanasiou, Petri Turhanen, Stephan I Brückner, Eike Brunner, Konstantinos D Demadis
ABSTRACT

Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.