- Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate.
Bioorganic & medicinal chemistry (2005-08-09)
Yuqiang Wang, Lianfa Li, Wei Jiang, James W Larrick
PMID16084097
ABSTRACT
We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon 38 adenocarcinoma. DHA-HCPT showed a greatly improved antitumor efficacy compared to HCPT.