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  • Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

Bioorganic & medicinal chemistry letters (2006-03-28)
Jay P Powers, Shyun Li, Juan C Jaen, Jinqian Liu, Nigel P C Walker, Zhulun Wang, Holger Wesche
PMID16563752
ABSTRACT

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.