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  • Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones.

Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones.

Chemical communications (Cambridge, England) (2006-10-07)
Sébastien L X Martina, Richard B C Jagt, Johannes G de Vries, Ben L Feringa, Adriaan J Minnaard
PMID17024259
ABSTRACT

The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.