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  • First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B.

Archiv der Pharmazie (2006-11-17)
Matthias Lotter, Johannes Schilling, Eberhard Reimann, Franz Bracher
PMID17109463
ABSTRACT

The one-pot reaction of 4-benzylpyridine-3-carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.