Skip to Content
Merck
  • Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.

Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.

Bioorganic & medicinal chemistry letters (2008-03-21)
Jinho Lee, Hwangeun Choi, Kyoung-Hee Kim, Shinwu Jeong, Jong-Wook Park, Chul-Su Baek, Sei-Hee Lee
PMID18353638
ABSTRACT

A novel series of 3,5-diaminoindazoles were prepared and found to be CDK inhibitors. Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole. Anti-proliferative activities of compounds were evaluated using EJ, HCT116, SW620, and A549 cancer cell lines.