- Catalytic amination of 2-substituted pyridines with hydrazine derivatives.
Catalytic amination of 2-substituted pyridines with hydrazine derivatives.
Organic letters (2001-05-12)
J B Arterburn, K V Rao, R Ramdas, B R Dible
PMID11348232
ABSTRACT
[reaction in text] Protected pyridylhydrazine derivatives were prepared in a one-step palladium-catalyzed amination reaction using chelating phosphine ligands. 2-Pyridyl chlorides, bromides, and triflates were effective electrophiles in these reactions. Di-tert-butyl hydrazodiformate was an excellent hydrazine substrate, and the resulting products were deprotected under mild conditions. Catalytic amination provides a direct route to protected bifunctional hydrazinopyridine linkers that are suitable for metal-bioconjugate syntheses.