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  • Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

Bioorganic & medicinal chemistry letters (2003-06-05)
Stefan Jaroch, Peter Hölscher, Hartmut Rehwinkel, Detlev Sülzle, Gerardine Burton, Margrit Hillmann, Fiona M McDonald
PMID12781178
ABSTRACT

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.