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Merck

Using neutron protein crystallography to understand enzyme mechanisms.

Acta crystallographica. Section D, Biological crystallography (2010-11-03)
Jenny P Glusker, H L Carrell, Andrey Y Kovalevsky, Leif Hanson, S Zoe Fisher, Marat Mustyakimov, Sax Mason, Trevor Forsyth, Paul Langan
PMID21041947
ABSTRACT

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated D-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.