Skip to Content
Merck
  • Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole.

Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole.

Chemical communications (Cambridge, England) (2008-03-28)
Jun-Long Zhang, Dewain K Garner, Lei Liang, Qian Chen, Yi Lu
PMID18368158
ABSTRACT

We demonstrate that incorporation of MnSalen into a protein scaffold enhances the chemoselectivity in sulfoxidation of thioanisole and find that both the polarity and hydrogen bonding of the protein scaffold play an important role in tuning the chemoselectivity.