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Merck

Pyrrolidine PNA: a novel conformationally restricted PNA analogue.

Organic letters (2001-01-11)
A Püschl, T Tedeschi, P E Nielsen
PMID11150189
ABSTRACT

[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.