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  • Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.

Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities.

Organic letters (2007-05-08)
Toshiyuki Kan, Yoichi Kita, Yuichi Morohashi, Yusuke Tominari, Shinnosuke Hosoda, Taisuke Tomita, Hideaki Natsugari, Takeshi Iwatsubo, Tohru Fukuyama
PMID17480083
ABSTRACT

Convenient synthesis of a variety of photoaffinity probes was accomplished by utilizing our Ns strategy and novel resin. The synthetic probes were evaluated via the labeling ability with the preseniline 1 C-terminal fragments, which was identified as a therapeutic target for Alzheimer's disease.