Skip to Content
Merck
  • Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.

Bioorganic & medicinal chemistry letters (2005-10-12)
Andrew Burchat, David W Borhani, David J Calderwood, Gavin C Hirst, Biqin Li, Robert F Stachlewitz
PMID16216497
ABSTRACT

We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.