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  • Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities.

Bioorganic & medicinal chemistry letters (2010-07-27)
Francis Giraud, Pascal Marchand, Delphine Carbonnelle, Michael Sartor, François Lang, Muriel Duflos
PMID20655209
ABSTRACT

N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.