SML1188

PYZD-4409

≥98% (HPLC)

• Synonym(s): 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
• Empirical Formula (Hill Notation): C₁₄H₇ClFN₃O₅
• CAS Number: 423148-78-1
• Molecular Weight: 351.67
• MDL number: MFCD01828668
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825708
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: , white to very dark brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC1=CC=C(N2C(C(C(N2)=O)=CC3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
• InChI: 1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H,(H,17,20)
• InChI key: MSYMKEYWUWVZQY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1 with an IC₅₀ of 20 mM. PYZD-4409 induces cell death, and inhbits clonogenic growth of leukemia and myeloma cell lines, and inhibits leukemia xenograft tumor growth in mice.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H315,H319,H335
• Precautionary Statements: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable