857123P

16:0 Lyso PA

Avanti Research^™ - A Croda Brand

• Synonym(s): 1-hexadecanoyl-sn-glycero-3-phosphate (sodium salt); palmitoyl lysophosphatidic acid; PA(16:0/0:0); 16:0 LPA; 110678
• Empirical Formula (Hill Notation): C₁₉H₃₈O₇PNa
• CAS Number: 17618-08-5
• Molecular Weight: 432.46
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
• Assay: >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
• form: powder
• packaging: pkg of 1 × 200 mg (857123P-200mg); pkg of 1 × 25 mg (857123P-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position.

Application

16:0 Lyso PA is suitable to use as an internal standard to extract lipids from plasma sample of ovarian cancer patients. It is also suitable for the preparation of lipid solutions for synthesizing liposomes.

Biochem/physiol Actions

Lysophosphatidic acid (LPA) participates in several biological functions. It acts as a potential biomarker for detecting ovarian cancer. LPA stimulates platelet aggregation, smooth muscle contraction, chemotaxis, cytoskeleton rearrangement, Ca²⁺ mobilization, neurotransmitter release and cell proliferation. Palmitoyl-lysophosphatidic acid helps in increasing aggregation, stimulated by adenosine diphosphate (ADP).

Packaging

5 mL Amber Glass Screw Cap Vial (857123P-200mg)

5 mL Amber Glass Screw Cap Vial (857123P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids