VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
Synonyms:
SKD1, SKD1A, SKD2, VPS4, VPS4-1
Species:
Human VPS4A (27183), Mouse Vps4a (116733), Rat Vps4a (246772), Zebrafish vps4a (767670), domestic cat VPS4A (101082613), dog VPS4A (479674), chicken VPS4A (425637), domestic guinea pig Vps4a (100724580), naked mole-rat Vps4a (101716007), Domestic Rabbit VPS4A (100340140) ...More
UniProtKB ID:
Gene ID:
- Human(27183) Summary: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]
- Mouse(116733) vacuolar protein sorting 4a (yeast)
- Rat(246772) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- Zebrafish(767670) vacuolar protein sorting 4a (yeast)
- domestic cat(101082613) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- dog(479674) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- chicken(425637) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- domestic guinea pig(100724580) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- naked mole-rat(101716007) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- Domestic Rabbit(100340140) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- cow(618168) vacuolar protein sorting 4 homolog A (S. cerevisiae)
- sheep(101112669) vacuolar protein sorting 4 homolog A (S. cerevisiae)
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