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Merck

UCP2

uncoupling protein 2 (mitochondrial, proton carrier)

Synonyms:
BMIQ4, SLC25A8, UCPH
Species:
Human UCP2 (7351), Mouse Ucp2 (22228), Rat Ucp2 (54315), naked mole-rat Ucp2 (101713667), domestic guinea pig Ucp2 (100727277), cow UCP2 (281562), sheep UCP2 (641300), sheep UCP2 (101104932), Thale Cress UCP2 (836014), domestic cat UCP2 (692194) ...More
UniProtKB ID:
P55851, Q4PJH8, Q53HM3
Gene ID:
  • Human(7351) Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
  • Mouse(22228) uncoupling protein 2 (mitochondrial, proton carrier)
  • Rat(54315) uncoupling protein 2 (mitochondrial, proton carrier)
  • naked mole-rat(101713667) uncoupling protein 2 (mitochondrial, proton carrier)
  • domestic guinea pig(100727277) uncoupling protein 2 (mitochondrial, proton carrier)
  • cow(281562) uncoupling protein 2 (mitochondrial, proton carrier)
  • sheep(641300) uncoupling protein 2 (mitochondrial, proton carrier)
  • sheep(101104932) uncoupling protein 2 (mitochondrial, proton carrier)
  • Thale Cress(836014) uncoupling protein 2
  • domestic cat(692194) uncoupling protein 2 (mitochondrial, proton carrier)
  • dog(403576) uncoupling protein 2 (mitochondrial, proton carrier)
  • Zebrafish(555812) uncoupling protein 2

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Antibodies

Product Number
Description
Species Reactivity
Application
AB3042
Anti-Uncoupling Protein 2 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
AB3040
Anti-Uncoupling Protein 2 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
AB3226
Anti-Uncoupling Protein 2 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
ELISA
western blot