TYMS
thymidylate synthetase
Synonyms:
HST422, TMS, TS
Species:
Human TYMS (7298), Mouse Tyms (22171), Rat Tyms (29261), domestic guinea pig Tyms (100720541), naked mole-rat Tyms (101721263), cow TYMS (507631), Zebrafish tyms (81540), chicken TYMS (421060), dog TYMS (607417), domestic cat TYMS (101091231)
UniProtKB ID:
Gene ID:
- Human(7298) Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
- Mouse(22171) thymidylate synthase
- Rat(29261) thymidylate synthetase
- domestic guinea pig(100720541) thymidylate synthetase
- naked mole-rat(101721263) thymidylate synthetase
- cow(507631) thymidylate synthetase
- Zebrafish(81540) thymidylate synthase
- chicken(421060) thymidylate synthetase
- dog(607417) thymidylate synthetase
- domestic cat(101091231) thymidylate synthetase
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