TSLP
thymic stromal lymphopoietin
Synonyms:
Species:
Human TSLP (85480), Mouse Tslp (53603), Rat Tslp (688621), domestic cat TSLP (101085857), Horse TSLP (100302635), dog TSLP (607671), domestic guinea pig Tslp (101788673)
UniProtKB ID:
Gene ID:
- Human(85480) Summary: This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
- Mouse(53603) thymic stromal lymphopoietin
- Rat(688621) thymic stromal lymphopoietin
- domestic cat(101085857) thymic stromal lymphopoietin
- Horse(100302635) thymic stromal lymphopoietin
- dog(607671) thymic stromal lymphopoietin
- domestic guinea pig(101788673) thymic stromal lymphopoietin
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