TNNI1
troponin I type 1 (skeletal, slow)
Synonyms:
SSTNI, TNN1
Species:
Human TNNI1 (7135), Mouse Tnni1 (21952), Rat Tnni1 (29388), cow TNNI1 (100301375), Goat TNNI1 (100860774), domestic guinea pig Tnni1 (100733717), naked mole-rat Tnni1 (101720739), chicken TNNI1 (421161), domestic cat TNNI1 (101096197), dog TNNI1 (100685160)
UniProtKB ID:
Gene ID:
- Human(7135) Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
- Mouse(21952) troponin I, skeletal, slow 1
- Rat(29388) troponin I type 1 (skeletal, slow)
- cow(100301375) troponin I type 1 (skeletal, slow)
- Goat(100860774) troponin I type 1 (skeletal, slow)
- domestic guinea pig(100733717) troponin I type 1 (skeletal, slow)
- naked mole-rat(101720739) troponin I type 1 (skeletal, slow)
- chicken(421161) troponin I type 1 (skeletal, slow)
- domestic cat(101096197) troponin I type 1 (skeletal, slow)
- dog(100685160) troponin I type 1 (skeletal, slow)
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