SQSTM1
sequestosome 1
Synonyms:
A170, OSIL, PDB3, ZIP3, p60, p62, p62B
Species:
Human SQSTM1 (8878), Mouse Sqstm1 (18412), Rat Sqstm1 (113894), Zebrafish sqstm1 (406452), dog SQSTM1 (481459), Horse SQSTM1 (100067231), domestic cat SQSTM1 (101085431), chicken SQSTM1 (770805), domestic guinea pig Sqstm1 (100725155), Domestic Rabbit SQSTM1 (100342157) ...More
UniProtKB ID:
Gene ID:
- Human(8878) Summary: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
- Mouse(18412) sequestosome 1
- Rat(113894) sequestosome 1
- Zebrafish(406452) sequestosome 1
- dog(481459) sequestosome 1
- Horse(100067231) sequestosome 1
- domestic cat(101085431) sequestosome 1
- chicken(770805) sequestosome 1
- domestic guinea pig(100725155) sequestosome 1
- Domestic Rabbit(100342157) sequestosome 1
- naked mole-rat(101724587) sequestosome 1
- cow(338045) sequestosome 1
- sheep(100135450) sequestosome 1
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