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Merck

SF3B1

splicing factor 3b, subunit 1, 155kDa

Synonyms:
Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155
Species:
Human SF3B1 (23451), Mouse Sf3b1 (81898), Rat Sf3b1 (84486), Zebrafish sf3b1 (446117), dog SF3B1 (488456), Horse SF3B1 (100070506), domestic cat SF3B1 (101088016), chicken SF3B1 (424056), cow SF3B1 (510177), sheep SF3B1 (101121573) ...More
UniProtKB ID:
O75533, E9PCH3
Gene ID:
  • Human(23451) Summary: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(81898) splicing factor 3b, subunit 1
  • Rat(84486) splicing factor 3b, subunit 1
  • Zebrafish(446117) splicing factor 3b, subunit 1
  • dog(488456) splicing factor 3b, subunit 1, 155kDa
  • Horse(100070506) splicing factor 3b, subunit 1, 155kDa
  • domestic cat(101088016) splicing factor 3b, subunit 1, 155kDa
  • chicken(424056) splicing factor 3b, subunit 1, 155kDa
  • cow(510177) splicing factor 3b, subunit 1, 155kDa
  • sheep(101121573) splicing factor 3b, subunit 1, 155kDa
  • Goat(100861148) splicing factor 3b, subunit 1, 155kDa
  • naked mole-rat(101707227) splicing factor 3b, subunit 1, 155kDa
  • domestic guinea pig(100723509) splicing factor 3b, subunit 1, 155kDa

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