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Merck

SET

SET nuclear oncogene

Synonyms:
2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA
Species:
Human SET (6418), Mouse Set (56086), Rat Set (307947), fruit fly Set (41844), domestic cat SET (101081583), dog SET (608952), chicken SET (417210), cow SET (538444), sheep SET (101118680), naked mole-rat Set (101720656)
UniProtKB ID:
Q01105, A5A5H4, A6NGV1, B4DUE2, Q15541, Q5VXV1, Q5VXV2, Q6FHZ5
Gene ID:
  • Human(6418) Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(56086) SET nuclear oncogene
  • Rat(307947) SET nuclear oncogene
  • fruit fly(41844) CG4299 gene product from transcript CG4299-RA
  • domestic cat(101081583) SET nuclear oncogene
  • dog(608952) SET nuclear oncogene
  • chicken(417210) SET nuclear oncogene
  • cow(538444) SET nuclear oncogene
  • sheep(101118680) SET nuclear oncogene
  • naked mole-rat(101720656) SET nuclear oncogene
  • domestic guinea pig(100715138) SET nuclear oncogene

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