ROCK1
Rho-associated, coiled-coil containing protein kinase 1
Synonyms:
P160ROCK, ROCK-I
Species:
Human ROCK1 (6093), Mouse Rock1 (19877), Rat Rock1 (81762), Zebrafish rock1 (100329779), dog ROCK1 (480181), Horse ROCK1 (100034056), chicken ROCK1 (373970), domestic guinea pig Rock1 (100718968), naked mole-rat Rock1 (101710589), Domestic Rabbit ROCK1 (100009220) ...More
UniProtKB ID:
Gene ID:
- Human(6093) Summary: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]
- Mouse(19877) Rho-associated coiled-coil containing protein kinase 1
- Rat(81762) Rho-associated coiled-coil containing protein kinase 1
- Zebrafish(100329779) Rho-associated, coiled-coil containing protein kinase 1
- dog(480181) Rho-associated, coiled-coil containing protein kinase 1
- Horse(100034056) Rho-associated, coiled-coil containing protein kinase 1
- chicken(373970) Rho-associated, coiled-coil containing protein kinase 1
- domestic guinea pig(100718968) Rho-associated, coiled-coil containing protein kinase 1
- naked mole-rat(101710589) Rho-associated, coiled-coil containing protein kinase 1
- Domestic Rabbit(100009220) Rho-associated, coiled-coil containing protein kinase 1
- cow(785911) Rho-associated, coiled-coil containing protein kinase 1
- sheep(100294662) Rho-associated, coiled-coil containing protein kinase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ROCK-1/2 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
western blot
Proteins
Product Number
Description
Species
ROKβ/ROCK-I Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant, human ROCK-I amino acids 17-535, autoactivated by incubating with Mg/ATP & redialysed to remove excess ATP. For use in Kinase Assays.,
Species
human
ROKα/ROCK-II Protein, active, rat, 10 µg, Active, rat, N-terminal, His-tagged, fusion protein corresponding to amino acids 2-543 of rat ROKa/ROCK-II. For use in Kinase Assays.,
Species
rat
ROKα/ROCK-II Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human ROCK-II residues 11-552, for use in Kinase Assays.,
Species
human