RNF128
ring finger protein 128, E3 ubiquitin protein ligase
Synonyms:
GRAIL
Species:
Human RNF128 (79589), Mouse Rnf128 (66889), Rat Rnf128 (315911), chicken RNF128 (422382), domestic cat RNF128 (101080265), dog RNF128 (492051), cow RNF128 (535869), sheep RNF128 (101117223), naked mole-rat Rnf128 (101698807), domestic guinea pig Rnf128 (100726928)
UniProtKB ID:
Gene ID:
- Human(79589) Summary: The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(66889) ring finger protein 128
- Rat(315911) ring finger protein 128, E3 ubiquitin protein ligase
- chicken(422382) ring finger protein 128
- domestic cat(101080265) ring finger protein 128, E3 ubiquitin protein ligase
- dog(492051) ring finger protein 128, E3 ubiquitin protein ligase
- cow(535869) ring finger protein 128, E3 ubiquitin protein ligase
- sheep(101117223) ring finger protein 128, E3 ubiquitin protein ligase
- naked mole-rat(101698807) ring finger protein 128, E3 ubiquitin protein ligase
- domestic guinea pig(100726928) ring finger protein 128, E3 ubiquitin protein ligase
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