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Merck

RIPK3

receptor-interacting serine-threonine kinase 3

Synonyms:
RIP3
Species:
UniProtKB ID:
Gene ID:
  • Human(11035) Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
  • Mouse(56532) receptor-interacting serine-threonine kinase 3
  • Rat(246240) receptor-interacting serine-threonine kinase 3
  • cow(507427) receptor-interacting serine-threonine kinase 3
  • sheep(101118877) receptor-interacting serine-threonine kinase 3
  • domestic guinea pig(100734737) receptor-interacting serine-threonine kinase 3
  • naked mole-rat(101719112) receptor-interacting serine-threonine kinase 3
  • dog(608486) receptor-interacting serine-threonine kinase 3
  • domestic cat(101097985) receptor-interacting serine-threonine kinase 3

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