PTPRJ
protein tyrosine phosphatase, receptor type, J
Synonyms:
CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1
Species:
Human PTPRJ (5795), Mouse Ptprj (19271), Rat Ptprj (29645), domestic guinea pig Ptprj (100729887), naked mole-rat Ptprj (101726039), Domestic Rabbit PTPRJ (100347798), cow PTPRJ (508150), sheep PTPRJ (101121292), chicken PTPRJ (395330), Horse PTPRJ (100058689) ...More
UniProtKB ID:
Gene ID:
- Human(5795) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(19271) protein tyrosine phosphatase, receptor type, J
- Rat(29645) protein tyrosine phosphatase, receptor type, J
- domestic guinea pig(100729887) protein tyrosine phosphatase, receptor type, J
- naked mole-rat(101726039) protein tyrosine phosphatase, receptor type, J
- Domestic Rabbit(100347798) protein tyrosine phosphatase, receptor type, J
- cow(508150) protein tyrosine phosphatase, receptor type, J
- sheep(101121292) protein tyrosine phosphatase, receptor type, J
- chicken(395330) protein tyrosine phosphatase, receptor type, J
- Horse(100058689) protein tyrosine phosphatase, receptor type, J
- domestic cat(101086598) protein tyrosine phosphatase, receptor type, J
- dog(483617) protein tyrosine phosphatase, receptor type, J
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