PTPN6
protein tyrosine phosphatase, non-receptor type 6
Synonyms:
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Species:
Human PTPN6 (5777), Mouse Ptpn6 (15170), Rat Ptpn6 (116689), domestic guinea pig Ptpn6 (100723417), naked mole-rat Ptpn6 (101725029), Domestic Rabbit PTPN6 (100348648), cow PTPN6 (512312), sheep PTPN6 (101108643), Zebrafish ptpn6 (335573), chicken PTPN6 (427947) ...More
UniProtKB ID:
Gene ID:
- Human(5777) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
- Mouse(15170) protein tyrosine phosphatase, non-receptor type 6
- Rat(116689) protein tyrosine phosphatase, non-receptor type 6
- domestic guinea pig(100723417) protein tyrosine phosphatase, non-receptor type 6
- naked mole-rat(101725029) protein tyrosine phosphatase, non-receptor type 6
- Domestic Rabbit(100348648) protein tyrosine phosphatase, non-receptor type 6
- cow(512312) protein tyrosine phosphatase, non-receptor type 6
- sheep(101108643) protein tyrosine phosphatase, non-receptor type 6
- Zebrafish(335573) protein tyrosine phosphatase, non-receptor type 6
- chicken(427947) protein tyrosine phosphatase, non-receptor type 6
- Horse(100052882) protein tyrosine phosphatase, non-receptor type 6
- domestic cat(101087073) protein tyrosine phosphatase, non-receptor type 6
- dog(486717) protein tyrosine phosphatase, non-receptor type 6
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