PTPN1
protein tyrosine phosphatase, non-receptor type 1
Synonyms:
PTP1B
Species:
Human PTPN1 (5770), Mouse Ptpn1 (19246), Rat Ptpn1 (24697), cow PTPN1 (508658), sheep PTPN1 (101118209), domestic guinea pig Ptpn1 (100730699), naked mole-rat Ptpn1 (101696680), Domestic Rabbit PTPN1 (100354834), Zebrafish ptpn1 (30081), Horse PTPN1 (100052066) ...More
UniProtKB ID:
Gene ID:
- Human(5770) Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
- Mouse(19246) protein tyrosine phosphatase, non-receptor type 1
- Rat(24697) protein tyrosine phosphatase, non-receptor type 1
- cow(508658) protein tyrosine phosphatase, non-receptor type 1
- sheep(101118209) protein tyrosine phosphatase, non-receptor type 1
- domestic guinea pig(100730699) protein tyrosine phosphatase, non-receptor type 1
- naked mole-rat(101696680) protein tyrosine phosphatase, non-receptor type 1
- Domestic Rabbit(100354834) protein tyrosine phosphatase, non-receptor type 1
- Zebrafish(30081) protein tyrosine phosphatase, non-receptor type 1
- Horse(100052066) protein tyrosine phosphatase, non-receptor type 1
- domestic cat(101099626) protein tyrosine phosphatase, non-receptor type 1
- dog(477263) protein tyrosine phosphatase, non-receptor type 1
- chicken(395688) protein tyrosine phosphatase, non-receptor type 1
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ELISA
Product Number
Description
Species
Small Molecule - Inhibitor
Kits
Product Number
Description
Species
PTP Assay Kit 1, PTP Assay Kit 1 can be used to detect PTP-1B activity by dephosphorylation of the phosphopeptide (RRLIEDAEpYAARG) using malachite green detection, or by hydrolysis of pNPP.,
Species
human