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Merck

PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Synonyms:
COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Species:
Human PTGS1 (5742), Mouse Ptgs1 (19224), Rat Ptgs1 (24693), Zebrafish ptgs1 (246226), dog PTGS1 (403544), Horse PTGS1 (100034087), domestic cat PTGS1 (101092557), chicken PTGS1 (427752), domestic guinea pig Ptgs1 (100714030), naked mole-rat Ptgs1 (101698854) ...More
UniProtKB ID:
P23219, A8K1V7, B4DHQ2, Q15122, Q5T7T6, Q5T7T7, Q5T7T8
Gene ID:
  • Human(5742) Summary: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
  • Mouse(19224) prostaglandin-endoperoxide synthase 1
  • Rat(24693) prostaglandin-endoperoxide synthase 1
  • Zebrafish(246226) prostaglandin-endoperoxide synthase 1
  • dog(403544) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(100034087) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(101092557) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • chicken(427752) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100714030) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • naked mole-rat(101698854) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • cow(282022) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443551) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

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Small Molecule - Inhibitor

Product Number
Description
Species
PHR1004
Ibuprofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
I1892
Ibuprofen sodium salt, ≥98% (GC),
Species
human
1457403
Naproxen sodium, United States Pharmacopeia (USP) Reference Standard,
Species
human
PHR1165
Naproxen sodium, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
PHR1144
Diclofenac sodium salt, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human